5-(4-amino-1-propan-2-yl-3-pyrazolo[3-4-d]pyrimidinyl)-1-3-benzoxazol-2-amine and posaconazole

5-(4-amino-1-propan-2-yl-3-pyrazolo[3-4-d]pyrimidinyl)-1-3-benzoxazol-2-amine has been researched along with posaconazole* in 1 studies

Other Studies

1 other study(ies) available for 5-(4-amino-1-propan-2-yl-3-pyrazolo[3-4-d]pyrimidinyl)-1-3-benzoxazol-2-amine and posaconazole

Article	Year
In Vitro Interactions between Target of Rapamycin Kinase Inhibitor and Antifungal Agents against Aspergillus Species. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:6 In vitro interactions of INK128, a target of rapamycin (TOR) kinase inhibitor, and antifungals, including itraconazole, voriconazole, posaconazole, amphotericin B, and caspofungin, against Aspergillus spp. were assessed with the broth microdilution checkerboard technique. Our results suggested synergistic effects between INK128 and all azoles tested, against multiple Aspergillus fumigatus and Aspergillus flavus isolates. However, no synergistic effects were observed when INK128 was combined with amphotericin B or caspofungin. No antagonism was observed for any combination. Topics: Amphotericin B; Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Benzoxazoles; Caspofungin; Drug Combinations; Drug Synergism; Echinocandins; Fungal Proteins; Gene Expression; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; TOR Serine-Threonine Kinases; Triazoles; Voriconazole	2016

Article

Year

In Vitro Interactions between Target of Rapamycin Kinase Inhibitor and Antifungal Agents against Aspergillus Species.

Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:6

In vitro interactions of INK128, a target of rapamycin (TOR) kinase inhibitor, and antifungals, including itraconazole, voriconazole, posaconazole, amphotericin B, and caspofungin, against Aspergillus spp. were assessed with the broth microdilution checkerboard technique. Our results suggested synergistic effects between INK128 and all azoles tested, against multiple Aspergillus fumigatus and Aspergillus flavus isolates. However, no synergistic effects were observed when INK128 was combined with amphotericin B or caspofungin. No antagonism was observed for any combination.

Topics: Amphotericin B; Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Benzoxazoles; Caspofungin; Drug Combinations; Drug Synergism; Echinocandins; Fungal Proteins; Gene Expression; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; TOR Serine-Threonine Kinases; Triazoles; Voriconazole

2016